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Updated: Aug 9, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery
Cheng Cheng1,2, Jiayun Ma1,2, Jinling Zhao2
1Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
Abstract:
Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
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