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Regenerative vs flap-based limb salvage: a multi-centered, prospective, randomized controlled trial.

Frank H Lau1, Ryan D Hoffman2, Denise Danos3

  • 1Department of Surgery, Louisiana State University Health Sciences Center New Orleans, Section of Plastic & Reconstructive Surgery, LA, USA.

Regenerative Medicine
|February 16, 2023
PubMed
Summary

Regenerative limb salvage (rLS) using dehydrated human chorion amnion membrane (dHACM) shows comparable success rates to traditional flap-based limb salvage (fLS) for complex extremity wounds. This regenerative approach offers an effective alternative for limb reconstruction.

Keywords:
dHACMflap reconstructionlimb salvageregenerative medicine

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Area of Science:

  • Regenerative medicine
  • Orthopedic surgery
  • Wound healing

Background:

  • Complex extremity wounds pose significant reconstructive challenges.
  • Traditional flap-based limb salvage (fLS) is a common but invasive treatment.
  • Novel regenerative approaches are needed to improve limb salvage outcomes.

Purpose of the Study:

  • To compare the success rates of regenerative limb salvage (rLS) using dehydrated human chorion amnion membrane (dHACM) with traditional fLS.
  • To evaluate outcomes including primary reconstruction success, exposed structure persistence, time to closure, and time to weight bearing.

Main Methods:

  • Prospective randomized controlled trial (RCT) over 3 years.
  • Patients with complex extremity wounds were randomized to fLS (n=14) or rLS (n=25).
  • Primary outcomes measured included reconstructive success and functional recovery metrics.

Main Results:

  • Primary reconstructive method success was 85.7% for fLS and 80% for rLS (p=1.00).
  • No statistically significant difference in success rates between the two groups.
  • Comparable functional recovery times were observed between fLS and rLS.

Conclusions:

  • Regenerative limb salvage (rLS) using dHACM is an effective treatment option for complex extremity wounds.
  • rLS demonstrates comparable success rates to traditional fLS.
  • This study supports rLS as a viable alternative for limb salvage procedures.