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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Aortic Regurgitation I: Introduction01:15

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

Updated: Aug 9, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

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Changes in Aortic Diameter and Wall Strain in Progressing Abdominal Aortic Aneurysms.

Wojciech Derwich1, Tobias Keller2, Natalie Filmann3

  • 1Department of Vascular and Endovascular Surgery, University Hospital Frankfurt Goethe University, Frankfurt am Main, Germany.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|February 16, 2023
PubMed
Summary

Four-dimensional ultrasound (4D US) tracks changes in abdominal aortic aneurysm (AAA) wall strain over time. This imaging technique helps differentiate patient subgroups based on strain patterns, offering insights into aneurysm behavior.

Keywords:
abdominal aortic aneurysmfollow-upheterogeneitywall strain

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Last Updated: Aug 9, 2025

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Area of Science:

  • Cardiovascular Imaging
  • Biomechanical Analysis
  • Medical Ultrasound

Background:

  • Abdominal aortic aneurysm (AAA) rupture risk assessment is crucial.
  • Wall strain analysis offers new predictive perspectives for AAA rupture.
  • Four-dimensional ultrasound (4D US) is a developing tool for assessing AAA dynamics.

Purpose of the Study:

  • To investigate the capability of 4D US in detecting and characterizing wall strain changes during AAA follow-up.
  • To evaluate the utility of 4D US in monitoring longitudinal strain variations in AAA patients.

Main Methods:

  • Eighteen patients with AAA underwent 64 4D US scans over a median follow-up of 24.5 months.
  • Manual aneurysm segmentation and kinematic analysis were performed.
  • Evaluation included mean and peak circumferential strain and spatial heterogeneity.

Main Results:

  • Aneurysm diameter increased by 4% annually (P < .001).
  • Mean circumferential strain (MCS) showed a trend of increase (0.89% to 10.49% per year, P = .063), independent of diameter.
  • Subgroup analysis identified distinct patterns of MCS change and spatial heterogeneity (P < .05).

Conclusions:

  • 4D US effectively registers strain changes during AAA follow-up.
  • MCS tends to increase over time, irrespective of maximum aneurysm diameter.
  • Kinematic parameters from 4D US differentiate AAA patient subgroups, providing insights into aneurysm wall pathology.