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Updated: Aug 9, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Current hemoglobin thresholds in pediatric anesthesia - guidelines and studies.

Eva Wittenmeier¹, Yannick Komorek, Kristin Engelhard

¹Department of Anesthesiology, University Medical Centre of the Johannes Gutenberg University Mainz, Germany.

Current Opinion in Anaesthesiology

|February 16, 2023

Summary

This summary is machine-generated.

Restrictive transfusion triggers are safe for preterm infants in the intensive care unit (ICU). However, more research is needed on intraoperative transfusion thresholds in pediatric patients for better patient blood management (PBM).

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Area of Science:

Pediatric Anesthesiology
Hematology
Critical Care Medicine

Background:

Patient Blood Management (PBM) emphasizes restrictive transfusion triggers to minimize transfusions.
Evidence-based guidelines for hemoglobin (Hb) transfusion thresholds are crucial for pediatric patients, a vulnerable group.

Approach:

This review synthesizes findings from recent prospective and observational studies on pediatric transfusion thresholds.
It summarizes recommendations for transfusion triggers in perioperative and intensive care settings.

Key Points:

Restrictive transfusion triggers are effective and feasible in preterm infants in the ICU.
Observational studies reveal variability in Hb levels and differing transfusion practices (restrictive vs. liberal) based on infant age.
A significant gap exists in high-quality prospective studies on intraoperative transfusion triggers in pediatrics.

Conclusions:

While restrictive transfusion is supported in ICUs for preterm infants, a lack of intraoperative data hinders comprehensive pediatric PBM.
Further high-quality research, particularly randomized controlled trials, is essential to establish intraoperative transfusion guidelines for pediatric patients.