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Updated: Aug 9, 2025
Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
Otoendoscopic Tympanic Repair of Tympanic Perforations Secondary to Chronic Otitis Media Using Porcine
Context:
The most common cause of hearing loss is chronic otitis media. Patients often exhibit ear tightness, ear plugging, conductive hearing loss, and even secondary perforation of the tympanic membrane. Patients require antibiotics to improve symptoms, and some patients need surgical repair of the membrane.
Objective:
The study intended to examine the effects of two methods of surgical transplantation using porcine mesentery under an otoscope on the surgical outcomes of patients with tympanic-membrane perforation secondary to chronic otitis media, with the intent to provide a basis for clinical practice.
Design:
The research team conducted a retrospective case-controlled study.
Setting:
The study took place at the Sir Run Run Shaw Hospital of the College of Medicine at Zhejiang University in Hangzhou, Zhejiang, China.
Participants:
Participants were 120 patients with tympanic membrane perforations that were secondary to chronic otitis media who had been admitted to the hospital between December 2017 and July 2019.
Intervention:
The research team divided the participants into two groups according to the surgical indications for repair of their perforations: (1) for patients with the central type of perforations with a rich residual tympanic membrane, the surgeon used the internal implantation method, and (2) for patients with a marginal or central perforation with a low residual tympanic membrane, the surgeon used the interlayer implantation method. Both groups received the implantations under conventional microscopic tympanoplasty, and the Department of Otolaryngology Head & Neck Surgery at the hospital provided the porcine mesenteric material.
Outcome Measures:
The research team compared the differences between the groups in operation time, blood loss, changes in the level of hearing loss between baseline and postintervention, air-bone conductivity, treatment effects, and surgical complications.
Results:
The operation time and blood loss of the internal implantation group were significantly greater than those of interlayer implantation group (P < .05). At 12 months postintervention, one participant in the internal implantation group had perforation recurrence, and two participants in the interlayer implantation group had infections and two had perforation recurrence. No significant difference existed between the groups in the complication rate (P > .05).
Conclusions:
Endoscopic repair of tympanic membrane perforations that were secondary to chronic otitis media, using porcine mesentery as the material for implantation, is a reliable treatment with few complications and good postoperative hearing recovery.
Insights
Porcine mesentery transplantation effectively repairs chronic otitis media-related tympanic membrane perforations. This method offers reliable outcomes with good hearing recovery and minimal complications, making it a viable surgical option.
Area of Science:
- Otolaryngology
- Surgical Innovation
- Regenerative Medicine
Background:
- Chronic otitis media frequently causes hearing loss and tympanic membrane perforations.
- Surgical repair is often necessary for persistent perforations.
Purpose of the Study:
- To evaluate the surgical outcomes of two tympanic membrane repair techniques using porcine mesentery.
- To compare internal vs. interlayer implantation methods for perforations secondary to chronic otitis media.
Main Methods:
- Retrospective case-controlled study involving 120 patients.
- Two surgical techniques: internal implantation and interlayer implantation using porcine mesentery.
- Comparison of operation time, blood loss, hearing outcomes, and complications.
Main Results:
- Internal implantation required more operative time and blood loss than interlayer implantation.
- At 12 months, perforation recurrence was observed in one patient (internal) and two (interlayer).
- Infection occurred in two patients in the interlayer group; complication rates were not significantly different between groups.
Conclusions:
- Endoscopic repair of tympanic membrane perforations with porcine mesentery is a reliable treatment.
- The procedure demonstrates a low complication rate and good postoperative hearing recovery.
- This technique provides a solid basis for clinical practice in managing chronic otitis media-related perforations.
