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Circulating basophil counts in atopic individuals.

K M Reilly1, P L Yap, J Dawes

  • 1MRC/SNBTS Blood Components Assay Group, Edinburgh, UK.

International Archives of Allergy and Applied Immunology
|January 1, 1987
PubMed
Summary
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Absolute basophil counts are significantly elevated in atopic individuals compared to non-atopic individuals. These elevated basophil levels in allergy patients show stability over time, indicating potential diagnostic value.

Area of Science:

  • Immunology
  • Allergy Research
  • Hematology

Background:

  • Basophils play a role in allergic inflammation.
  • Accurate quantification of circulating basophils is crucial for understanding allergic diseases.

Purpose of the Study:

  • To compare absolute basophil counts between atopic and non-atopic individuals.
  • To assess the stability of basophil counts over short and long periods.

Main Methods:

  • Automated cell counting using flow cytometry.
  • Comparison of absolute basophil and total leucocyte counts.
  • Sequential blood sampling for stability assessment.

Main Results:

  • Absolute basophil counts were significantly higher in atopic individuals (p < 0.001).

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  • Eosinophil counts also correlated with and were elevated in atopic individuals.
  • No significant variation in basophil counts was observed over 5 days or 20 months.

    • Conclusions:

    • Elevated absolute basophil counts are a characteristic feature of atopy.
    • Basophil counts demonstrate stability in individuals, suggesting reliability for clinical assessment.
    • Flow cytometry provides a reliable method for quantifying basophils in allergy research.