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Indocyanine green pharmacokinetics calculations using Lotus 123 spreadsheet
1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
International Journal of Bio-Medical Computing
|November 1, 1987
Summary
This study introduces a computer program for calculating Indocyanine green (ICG) pharmacokinetics, improving accuracy and speed for liver function tests. The program utilizes Lotus 123 for precise mathematical analysis, enhancing clinical utility.
Area of Science:
- Pharmacology
- Medical Technology
- Hepatology
Background:
- Indocyanine green (ICG) is a vital dye for assessing liver function.
- Accurate pharmacokinetic values are crucial for reliable liver function determinations.
- Graphical methods for ICG analysis lack the precision of mathematical calculations.
Purpose of the Study:
- To develop a computational method for accurate and efficient Indocyanine green (ICG) pharmacokinetic analysis.
- To streamline the calculation process for liver function tests using ICG.
- To enhance the precision of ICG pharmacokinetic determinations through mathematical modeling.
Main Methods:
- Development of a program using Lotus 123 spreadsheet software.
- Implementation of linear and log-linear regression analyses for ICG data.
- Utilizing an IBM compatible computer for expedited calculations.
Main Results:
- The developed program accurately calculates pharmacokinetic values for Indocyanine green (ICG).
- Mathematical calculations performed by the program are more accurate than graphical methods.
- Significant reduction in calculation time for ICG pharmacokinetic analysis was achieved.
Conclusions:
- A Lotus 123-based program provides an accurate and efficient method for ICG pharmacokinetic analysis.
- This computational approach enhances the reliability of liver function tests.
- The program facilitates faster and more precise clinical decision-making based on ICG data.