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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
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Altered States of Awareness01:06

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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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Psychotherapy01:28

Psychotherapy

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Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
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Psychodynamic Therapy01:29

Psychodynamic Therapy

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Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
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An Overview of Psychoactive Drugs01:28

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Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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Possible psychedelic therapeutic mechanism.

Evan M Hess1, Todd D Gould1,2,3,4

  • 1Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

Science (New York, N.Y.)
|February 16, 2023
PubMed
Summary
This summary is machine-generated.

Psychedelics, like psilocybin, uniquely activate serotonin receptors inside brain cells. This intracellular action differs from how the body

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Serotonin is a key neurotransmitter regulating mood and cognition.
  • Traditional antidepressants primarily target extracellular serotonin receptors.

Purpose of the Study:

  • To elucidate the unique mechanism of psychedelic action.
  • To investigate the role of intracellular serotonin receptors.

Main Methods:

  • Utilizing advanced molecular biology techniques.
  • Analyzing the interaction of psychedelic compounds with specific receptor subtypes.

Main Results:

  • Psychedelics bind to serotonin receptors located within the cell.
  • These intracellular receptors are not directly activated by endogenous serotonin.

Conclusions:

  • Psychedelics engage a distinct signaling pathway compared to conventional serotonergic drugs.
  • This intracellular mechanism may explain the profound and long-lasting effects of psychedelics.