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Related Concept Videos

Brain Imaging01:14

Brain Imaging

274
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Neuroimaging in Dementia.

Shannon L Risacher1, Liana G Apostolova

  • 1Address correspondence to Dr Shannon L. Risacher, 355 W 16th St, Indianapolis, IN 46202, srisache@iupui.edu .

Continuum (Minneapolis, Minn.)
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Summary
This summary is machine-generated.

Neuroimaging techniques like MRI and PET are crucial for diagnosing neurodegenerative diseases. These advanced tools help detect brain changes, aiding in the early and accurate diagnosis of conditions such as Alzheimer's disease.

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Area of Science:

  • Neuroscience
  • Radiology
  • Biomarker Discovery

Background:

  • Neurodegenerative diseases pose significant global health challenges.
  • Accurate diagnosis is critical for effective management and treatment strategies.

Approach:

  • This review examines neuroimaging biomarkers for detecting and diagnosing various neurodegenerative diseases.
  • It covers Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and Single-Photon Emission Computed Tomography (SPECT).

Key Points:

  • MRI and PET reveal distinct patterns of brain atrophy and hypometabolism, aiding differential diagnosis.
  • Advanced MRI techniques (diffusion, fMRI) offer insights into biological changes.
  • Molecular imaging visualizes proteinopathies and neurotransmitter levels associated with dementia.

Conclusions:

  • Neuroimaging is transforming the diagnosis of neurodegenerative diseases beyond traditional symptomatology.
  • These in vivo tools are essential for both clinical diagnosis and research advancement.