LONG-TERM EVOLUTION OF MYOPIC RETINOSCHISIS WITH A DOME-SHAPED MACULA AND PREDICTORS OF PROGRESSION AND VISUAL...

Area of Science:

• Ophthalmology
• Retinal Diseases
• Myopia Research

Background:

• Myopic retinoschisis (MRS) is a degenerative condition affecting the retina.
• Dome-shaped macula (DSM) is an anatomical variation that may influence retinal diseases.

Purpose of the Study:

• To investigate the long-term natural course of myopic retinoschisis (MRS) in eyes with a dome-shaped macula (DSM).
• To identify factors influencing the development and visual prognosis of MRS in the presence of a DSM.

Main Methods:

• A retrospective case series study involving 25 eyes with MRS and DSM, and 68 eyes with MRS but without DSM.
• Follow-up duration of at least two years, monitoring optical coherence tomography (OCT) findings and best-corrected visual acuity (BCVA).

Main Results:

• No significant difference in MRS progression rate between DSM and non-DSM groups (P = 0.7462).
• In the DSM group, older age and higher refractive error correlated with MRS progression (P = 0.0301, P = 0.0166).
• Central foveal DSM location showed a higher progression rate (P = 0.0421); greater initial central foveal thickness predicted BCVA decrease (P = 0.0478).

Conclusions:

• A DSM does not impede the progression of myopic retinoschisis.
• MRS development in DSM eyes is associated with patient age, myopic degree, and DSM location.
• While a larger schisis cavity predicts visual decline, a DSM may preserve visual function in extrafoveal MRS.