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Recent insights into comorbidities in atopic dermatitis.
Caroline Gewiss1, Matthias Augustin1
1Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Expert Review of Clinical Immunology
|February 16, 2023
Summary
Atopic dermatitis is linked to both atopic and non-atopic conditions, indicating it is a systemic disease. Further research into these comorbidities is crucial for developing targeted therapies.
Area of Science:
- Dermatology
- Immunology
- Internal Medicine
Background:
- Atopic dermatitis is commonly associated with atopic diseases like asthma and allergic rhinitis.
- Emerging evidence highlights links between atopic dermatitis and non-atopic comorbidities, including cardiac, autoimmune, and neuropsychological conditions, as well as infections.
- These associations suggest atopic dermatitis functions as a systemic disease.
Purpose of the Study:
- To review the existing evidence on atopic and non-atopic comorbidities associated with atopic dermatitis.
- To explore the co-occurrence, mechanisms, and therapeutic implications of these comorbidities.
Main Methods:
- A comprehensive literature search was performed using PubMed.
- Peer-reviewed articles published up to October 2022 were included in the review.
Main Results:
- Atopic and non-atopic diseases frequently co-occur with atopic dermatitis beyond chance expectations.
- The impact of novel treatments like biologics and small molecules on comorbidities offers insights into their interconnectedness.
Conclusions:
- The coexistence of atopic and non-atopic diseases with atopic dermatitis is significant.
- Further investigation into the underlying mechanisms is essential for advancing an endotype-based therapeutic strategy for atopic dermatitis.
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