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Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses
K Róna1, B Gachályi, L Vereczkey
1Postgraduate Medical School, 1st Department of Internal Medicine, Budapest, Hungary.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|September 1, 1987
Abstract:
Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance, was investigated in a crossover study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, Vd, AUC, t1/2) indicating that the two preparations are bioequivalent.