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Early auditory processing dysfunction in schizophrenia: Mechanisms and implications
Clément Dondé1, Joshua T Kantrowitz2, Alice Medalia3
1Univ. Grenoble Alpes, F-38000 Grenoble, France; INSERM, U1216, F-38000 Grenoble, France; Psychiatry Department, CHU Grenoble Alpes, F-38000 Grenoble, France; Psychiatry Department, CH Alpes-Isère, F-38000 Saint-Egrève, France.
Neuroscience and Biobehavioral Reviews
|February 16, 2023
Summary
Early auditory processing deficits are central to schizophrenia, impacting cognition and social function. These impairments offer potential targets for new treatments and understanding the disorder's causes.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Schizophrenia affects 1% of the global population, characterized by cognitive deficits and disability.
- Impaired early auditory perception is a well-documented feature in schizophrenia.
- Auditory dysfunction is linked to higher-order cognitive and social cognitive deficits.
Purpose of the Study:
- To review early auditory dysfunction in schizophrenia from behavioral and neurophysiological viewpoints.
- To explore the link between auditory processing, cognitive functions, and social cognition.
- To discuss the role of glutamatergic and N-methyl-D-aspartate receptor (NMDAR) dysfunction in schizophrenia pathophysiology.
- To examine the potential of auditory measures as treatment targets and biomarkers.
Main Methods:
- Literature review synthesizing behavioral and neurophysiological findings.
- Analysis of the relationship between early auditory processing and cognitive/social deficits.
- Examination of pathological mechanisms, focusing on glutamatergic and NMDAR pathways.
- Discussion of translational applications of auditory measures.
Main Results:
- Early auditory deficits are consistently observed in schizophrenia patients.
- These deficits correlate with impairments in complex cognition and social cognition.
- Glutamatergic and NMDAR dysfunction are implicated in the underlying pathology.
- Early auditory measures show promise as biomarkers and therapeutic targets.
Conclusions:
- Early auditory deficits play a critical role in schizophrenia pathophysiology.
- Addressing auditory processing offers a promising avenue for precision intervention.
- Auditory measures are valuable for etiological research and biomarker development.
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