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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
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Novel biomarkers associated with thoracic aortic disease
Carlijn G E Thijssen1, Silvy Dekker2, Lidia R Bons2
1Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.
International Journal of Cardiology
|February 16, 2023
Summary
Matrix Metalloproteinase-3 (MMP-3) and Insulin-like growth factor binding protein 2 (IGFBP-2) are associated with thoracic aortic disease (TAD) severity. Further research is needed to explore their clinical utility in TAD diagnosis and management.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Thoracic Aortic Disease Research
Background:
- Thoracic aortic disease (TAD) diagnosis, surveillance, and risk stratification can be improved using biomarkers.
- This study investigated the association between various cardiovascular biomarkers and clinical characteristics in TAD patients.
Purpose of the Study:
- To explore the relationship between a wide range of cardiovascular biomarkers and clinical features in patients with thoracic aortic disease (TAD).
- To identify specific biomarkers associated with thoracic aortic diameter and disease severity in TAD patients.
Main Methods:
- 158 clinically stable TAD patients provided venous blood samples.
- Olink multiplex platform analyzed 92 proteins for biomarker levels.
- Linear regression identified biomarker associations with absolute (ADmax) and indexed (IDmax) thoracic aortic diameter.
Main Results:
- Matrix Metalloproteinase-3 (MMP-3) and Insulin-like growth factor binding protein 2 (IGFBP-2) showed significant positive associations with ADmax and IDmax, respectively.
- Patients with prior aortic surgery/dissection had elevated N-terminal-pro hormone BNP (NTproBNP).
- Hereditary TAD patients exhibited higher Trem-like transcript protein 2 (TLT-2) levels.
Conclusions:
- MMP-3 and IGFBP-2 are linked to disease severity in TAD patients.
- The pathophysiological roles and clinical applications of these biomarkers require further investigation.
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