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A Lesion-Derived Brain Network for Emotion Regulation.

Jing Jiang1, Michael A Ferguson2, Jordan Grafman3

  • 1Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Boston, Massachusetts; Department of Neurology, Harvard Medical School, Boston, Massachusetts.

Biological Psychiatry
|February 16, 2023
PubMed
Summary

This study identifies a brain network crucial for emotion regulation, centered on the left ventrolateral prefrontal cortex. Damage to this network impairs emotion management and increases the risk of neuropsychiatric conditions.

Keywords:
Brain lesionEmotion regulationFunctional connectivityLesion network mappingfMRI

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Brain Imaging

Background:

  • Functional neuroimaging links emotion regulation to specific brain networks.
  • Causal brain networks for emotion regulation remain unidentified.

Purpose of the Study:

  • To identify the causal brain network for emotion regulation using lesion data.
  • To investigate the relationship between damage to this network and emotion regulation deficits.
  • To examine the association between this network and neuropsychiatric conditions.

Main Methods:

  • Studied 167 patients with focal brain damage assessing emotion regulation.
  • Utilized lesion network mapping to derive a novel brain network for emotion regulation.
  • Validated the network in an independent lesion database of 629 patients.

Main Results:

  • Lesions intersecting the a priori network impaired emotion regulation.
  • The derived emotion regulation network is functionally connected to the left ventrolateral prefrontal cortex.
  • Lesions within this network were associated with mania, criminality, and depression.

Conclusions:

  • Emotion regulation is associated with a brain network centered on the left ventrolateral prefrontal cortex.
  • Damage to this network causes difficulties in managing emotions.
  • This network is implicated in the risk for several neuropsychiatric disorders.