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Chronic kidney disease mineral and bone disorder: A guide for general practice

Krita Sridharan1

  • 1MBBS (Hons), General and Acute Care Medicine Advanced Physician Trainee, The Alfred Hospital, Melbourne, Vic; Adjunct Lecturer, Central Clinical School, Monash University, Melbourne, Vic.

Australian Journal of General Practice
|February 16, 2023
PubMed

Insights

General practitioners can screen and manage chronic kidney disease mineral and bone disorder (CKD-MBD) starting in stage 3a CKD. Early intervention improves bone health and reduces cardiovascular risk in CKD patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Chronic kidney disease mineral and bone disorder (CKD-MBD) significantly increases morbidity, cardiovascular risk, and mortality in chronic kidney disease (CKD) patients.
  • CKD-MBD manifestations begin as early as stage 3a CKD.
  • General practitioners are vital for community-based screening, monitoring, and early management of CKD-MBD.

Approach:

  • This article summarizes evidence-based principles for understanding CKD-MBD pathogenesis.
  • It details current assessment strategies for CKD-MBD.
  • It reviews a spectrum of management approaches for CKD-MBD.

Key Points:

  • CKD-MBD encompasses biochemical abnormalities, bone disease, and calcification of soft tissues and vasculature.
  • Management focuses on monitoring and controlling biochemical parameters.
  • Strategies aim to enhance bone health and mitigate cardiovascular risk.

Conclusions:

  • Effective management of CKD-MBD requires a comprehensive approach addressing its multifaceted nature.
  • Early detection and intervention by general practitioners are crucial for improving patient outcomes.
  • Evidence-based treatments are available to manage CKD-MBD and its associated complications.
Abstract

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