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Updated: Jul 28, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Clinical Reasoning: Progressive Hemiparesis and White Matter Abnormalities in an HIV-Negative Patient
Edwin Jabbari1, Fernanda Ruiz2, Simon F K Lee2
1From the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom. edwin.jabbari@nhs.net.
Abstract:
A 61-year-old man from India was admitted to hospital after being found unresponsive by the roadside. He was treated with dual-antiplatelet therapy for an acute coronary syndrome. Ten days into admission, he had mild left-sided face, arm, and leg weakness, which progressed significantly over the next 2 months in association with progressive white matter abnormalities on brain MRI. In this case study, we outline our clinical reasoning, which led to the detection of a rare underlying cause of a devastating neurologic disease. We also present our approach to treatment, which achieved a sustained clinical and radiologic response.
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