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Updated: Aug 9, 2025

Metagenomic Analysis of Silage
Published on: January 13, 2017
Impact of microbial genome completeness on metagenomic functional inference
Raphael Eisenhofer1, Iñaki Odriozola1, Antton Alberdi2
1Center for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Abstract:
Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.
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