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Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients

Yixuan Zhong1, Yiyi Wu1,2, Yunyun Yang3

  • 1National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100037, China.

Journal of Human Genetics
|February 16, 2023
PubMed

Insights

Genetic variants in the MPPED2 gene influence kidney function in hypertensive patients. The rs10767873 variant is linked to higher estimated glomerular filtration rate and increased cardiovascular disease risk.

Area of Science:

  • Genetics
  • Nephrology
  • Cardiology

Background:

  • Kidney function changes and chronic kidney disease (CKD) progression are linked to cardiovascular disease (CVD) risk.
  • Genetic factors influence these associations, but their role in hypertensive patients on medication is unclear.

Purpose of the Study:

  • To investigate the association between genetic variants and kidney function (eGFR) in Chinese hypertensive patients.
  • To explore the relationship between these variants and the risk of CVD events.

Main Methods:

  • Analyzed 30 variants in 22 genes in 1911 hypertensive patients (1220 with CKD).
  • Used multivariate linear regression, adjusting for risk factors and antihypertensive drug use.
  • Followed patients for a median of 2.25 years to document CVD events.

Main Results:

  • The MPPED2 gene variant rs10767873T allele was associated with higher eGFR, lower serum creatinine, and lower serum uric acid.
  • This variant did not correlate with CKD risk, irrespective of antihypertensive drug type.
  • Patients with the rs10767873TT genotype showed a significantly increased risk of CVD events (HR=1.74).

Conclusions:

  • The MPPED2 gene variant rs10767873 is associated with kidney function in Chinese hypertensive individuals.
  • This genetic variant is also linked to an elevated risk of cardiovascular disease events in this population.

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