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Related Experiment Video

Updated: Aug 9, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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[Immunomodulation by nutritional intervention in critically ill patients].

Simon Hirschberger1,2, Annika Schmid1,2, Simone Kreth3,4

  • 1Klinik für Anaesthesiologie, LMU Klinikum München, München, Deutschland.

Die Anaesthesiologie
|February 16, 2023
PubMed
Summary

Critically ill patients experience immune dysfunction due to metabolic processes. Immunonutrition strategies, including supplements and diet modulation, show potential for improving immune function in intensive care units.

Keywords:
Immunometabolic paralysisImmunonutritionKetogenic dietMacronutrientsMicrobiome

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Area of Science:

  • Immunology
  • Metabolism
  • Critical Care Medicine

Context:

  • Critically ill patients frequently exhibit complex immunological dysfunction.
  • Immune cell differentiation and function are intrinsically linked to metabolic processes.
  • Intensive care unit (ICU) settings present unique challenges for patient recovery.

Purpose:

  • To review current evidence on isolated immunonutrition supplements for critically ill patients.
  • To explore novel immunonutrition concepts, including microbiome modulation and macronutrient composition.
  • To assess the potential of immunonutrition as a clinical tool in intensive care.

Summary:

  • This review examines the use of isolated supplements like anti-oxidative substances, amino acids, and essential fatty acids in immunonutrition.
  • It discusses the challenges associated with the clinical application of these individual components.
  • The review also introduces advanced immunonutrition strategies focusing on the gut microbiome and macronutrient balance.

Impact:

  • Immunonutrition holds significant potential for positively influencing immune function in critically ill patients.
  • Modulating immunometabolism through nutrition may become a key therapeutic approach in intensive care.
  • Further research into comprehensive immunonutrition strategies could enhance patient outcomes.