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Updated: Aug 9, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Periodic epidemic outbursts explained by local saturation of clusters
Louis Gostiaux1, Wouter J T Bos1, Jean-Pierre Bertoglio1
1Univ Lyon, École Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Mécanique des Fluides et d'Acoustique, UMR 5509, 36 Avenue Guy de Collongue, F-69134 Ecully, France.
Abstract:
Adding the notion of spatial locality to the susceptible-infected-recovered (or SIR) model, allows to capture local saturation of an epidemic. The resulting minimum model of an epidemic, consisting of five ordinary differential equations with constant model coefficients, reproduces slowly decaying periodic outbursts, as observed in the COVID-19 or Spanish flu epidemic. It is shown that if immunity decays, even slowly, the model yields a fully periodic dynamics.
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