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Risk Factors of Exchange Blood Transfusion in Infants With Severe Pertussis

Tingting Shi1, Shuling Du2, Huifeng Fan1

  • 1Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Clinical Pediatrics
|February 17, 2023
PubMed

Insights

Exchange blood transfusion (ET) can improve outcomes for severe pertussis patients. This therapy is recommended for infants with high fever, elevated C-reactive protein (CRP), and high white blood cell (WBC) counts.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Severe pertussis can lead to life-threatening complications.
  • Intensive therapeutic measures may not always be sufficient for severe pertussis cases.

Purpose of the Study:

  • To assess the effectiveness of exchange blood transfusion (ET) in severe pertussis.
  • To identify risk factors associated with the need for ET in infants with severe pertussis.

Main Methods:

  • Retrospective analysis of medical records of 12 severe pertussis patients requiring ET.
  • Statistical analysis to determine independent risk factors for ET.

Main Results:

  • Eight out of 12 patients (66.7%) survived after ET.
  • Independent risk factors for ET included temperature ≥ 38.5°C, C-reactive protein (CRP) >30 mg/L, and white blood cell (WBC) count > 40.0 × 10^9/L.
  • ET demonstrated effectiveness in improving outcomes for severe pertussis.

Conclusions:

  • Exchange blood transfusion is a potentially effective therapy for severe pertussis.
  • Consider ET for severe pertussis patients presenting with high fever, elevated CRP, and high WBC counts.

Keywords:
exchange blood transfusioninfantspertussisrisk factor

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