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Guidelines for genetic ancestry inference created through roundtable discussions.

Jennifer K Wagner1,2,3,4,5,6, Joon-Ho Yu7,8, Duana Fullwiley9

  • 1School of Engineering Design and Innovation, Pennsylvania State University, University Park, PA 16802, USA.

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Summary
This summary is machine-generated.

Guidelines for inferring genetic ancestry were developed through stakeholder engagement. These guidelines address key areas like methods, terminology, and communication to improve best practices in research and consumer testing.

Keywords:
ELSIgenetic ancestrypopulation descriptorsrace and ethnicity

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Area of Science:

  • Genetics and Genomics
  • Bioethics

Background:

  • Genetic and genomic technologies are widely used for ancestry inference in biomedical research and direct-to-consumer testing.
  • Previous stakeholder roundtables in 2013 and 2015 aimed to establish guidelines for genetic ancestry inference.

Purpose of the Study:

  • To report on the work of stakeholder groups in developing guidelines for genetic ancestry inference.
  • To analyze and comment on the dialogue and resulting statements from these stakeholder groups.

Main Methods:

  • Convening diverse stakeholders in roundtables.
  • Describing engagement processes and analyzing resulting statements and proposed guidelines.
  • Focusing on five key areas: application, methods, terminology, impact, and communication.

Main Results:

  • Development of proposed guidelines for inferring genetic ancestry.
  • Guidelines cover critical aspects including methods, terminology, and communication.
  • Identification of terms and limitations of the guidelines.

Conclusions:

  • The developed guidelines are crucial for advancing best practices in genetic ancestry inference and reporting.
  • These guidelines should inform both governmental regulation and industry self-regulation.
  • The report highlights the importance of sustained dialogue among diverse stakeholders.