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Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing.

Eric H Pollmann, Heyu Yin, Ilke Uguz

    Biorxiv : the Preprint Server for Biology
    |February 17, 2023
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed an ultrathin, implantable optical probe for brain-machine interfaces. This new device enables precise monitoring and manipulation of neural activity, paving the way for future human applications.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Optoelectronics

    Background:

    • Optical neurotechnologies offer high-precision neural monitoring and manipulation.
    • Current devices are too bulky for full implantation, hindering human translation.
    • A minimally invasive, implantable form factor is crucial for advancing brain-machine interfaces.

    Approach:

    • Developed the subdural CMOS Optical Probe (SCOPe), an ultrathin, miniaturized device.
    • Leveraged advances in microelectronics and heterogeneous optoelectronic packaging.
    • Designed SCOPe for bidirectional optical stimulation and recording within the subdural space.

    Key Points:

    • SCOPe is thin enough for subdural placement in the primate brain.
    • The device integrates microelectronics and optoelectronics for advanced functionality.
    • Enables precise, large-area monitoring and manipulation of neural activity.

    Conclusions:

    • SCOPe represents a significant advancement towards fully implantable optical neurotechnology.
    • This technology defines a path for the human translation of next-generation brain-machine interfaces.
    • The development addresses the critical need for noninvasive, miniaturized neural interfaces.