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Insulin-like peptide 6 (INSL6) shows altered expression in myocardial infarction (MI) and breast cancer (BRCA). Lower INSL6 levels correlate with worse prognosis, suggesting INSL6 as a potential biomarker for cancer progression and survival.

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Area of Science:

  • Oncology
  • Cardiology
  • Genomics

Background:

  • Myocardial infarction (MI) exacerbates early-stage breast cancer (BRCA) progression, increasing patient mortality.
  • Insulin-like peptide 6 (INSL6) plays a role in MI progression by aiding myofiber regeneration.
  • The role of INSL6 in various malignant tumors requires further investigation.

Purpose of the Study:

  • To explore the significance of INSL6 in diverse cancers using integrated omics data.
  • To evaluate INSL6 as a diagnostic and prognostic biomarker in pancancer and specifically in BRCA.
  • To analyze the correlation between INSL6 expression, clinical characteristics, and tumor progression in BRCA.

Main Methods:

  • Integrative analysis of MI GEO dataset and multiple omics data (gene expression, pathway enrichment, PPI).
  • Pancancer analysis including immune subtypes, diagnostic, and prognostic value assessment.
  • Detailed investigation in BRCA, focusing on clinical correlations, subgroup prognosis, coexpression, DEGs, and PPI networks.

Main Results:

  • INSL6 expression was downregulated in the MI group.
  • INSL6 demonstrated significant differential expression across most cancers and subtypes.
  • Lower INSL6 expression correlated with worse overall and disease-specific survival in BRCA subgroups, indicating its prognostic value.

Conclusions:

  • INSL6 may serve as a potential diagnostic and prognostic biomarker for various cancers, including BRCA.
  • Aberrant INSL6 expression is linked to tumor progression and immune cell infiltration, particularly in KIRP and BRCA.
  • The study highlights a potential crosstalk between MI and tumor progression involving INSL6.