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Dexamphetamine influences funneling illusion based on psychometric score.

Faiz M Kassim¹, J H Mark Lim¹, Matthew A Albrecht²

¹Neuropsychopharmacology Research Unit, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.

Human Psychopharmacology

|February 17, 2023

Summary

Dexamphetamine did not alter unimodal illusions like the Tactile Funneling Illusion (TFI) in healthy adults. However, changes in psychometric scores after dexamphetamine positively correlated with altered funneling perception, suggesting indirect dopamine influence.

Keywords:

dexamphetamine dopamine funneling psychosis psychotomimetic tactile illusion

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Area of Science:

Neuroscience
Psychology

Background:

Previous research indicated dexamphetamine broadens binding windows in multimodal illusions (Rubber Hand Illusion) for individuals with schizophrenia and their offspring.
The effect of dexamphetamine on unimodal sensory illusions and its relationship with personality variations remains unclear.

Purpose of the Study:

To investigate the impact of dexamphetamine (DEX), a dopamine-releasing stimulant, on illusory perception using the unimodal Tactile Funneling Illusion (TFI).
To examine temporal and spatial variables in TFI perception following DEX administration.
To explore the correlation between changes in psychometric scores and DEX-induced alterations in illusion perception.

Main Methods:

A randomized, double-blind, placebo-controlled, cross-over study involving 20 healthy subjects.
Administration of dexamphetamine (0.45 mg/kg) or placebo.
Assessment of the Tactile Funneling Illusion (TFI) for funneling and spatial localization errors, alongside psychotomimetic effects via psychological measures.

Main Results:

Dexamphetamine did not significantly alter the funneling illusion or spatial localization error compared to placebo.
A significant positive correlation was observed between changes in psychometric scores and alterations in funneling perception after dexamphetamine.
This correlation was particularly notable under the 0 ms delay condition.

Conclusions:

Dopamine-releasing agents like dexamphetamine do not appear to alter binding windows in unimodal illusions, unlike their effect on multimodal illusions.
Psychotomimetic effects of dexamphetamine indirectly influence unimodal illusion perception, as evidenced by the correlation with psychometric score changes.