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Role of the Notch1 signaling pathway in ischemic heart disease (Review)

Xiafeng Peng1, Shixin Wang1, Hongwu Chen1

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

International Journal of Molecular Medicine
|February 17, 2023
PubMed

Insights

Aberrant Notch1 signaling is common in ischemic heart disease (IHD). Targeting Notch1 may improve treatments for IHD patients by influencing cellular processes and repair mechanisms.

Area of Science:

  • Cardiovascular Biology
  • Molecular Signaling
  • Cellular Biology

Background:

  • Ischemic heart disease (IHD) involves atherosclerotic plaque development and rupture.
  • The Notch signaling pathway is crucial for intercellular communication.
  • Aberrant Notch1 signaling is consistently observed in IHD, indicating its clinical relevance.

Approach:

  • This review summarizes Notch1 signaling's role in endothelial cells, vascular smooth muscle cells, and macrophages during IHD development.
  • It examines Notch1's effects on IHD remodeling stages: reendothelialization, neovascularization, and myocardial fibrosis.
  • The review discusses Notch1's involvement in reperfusion therapies and cardiac regeneration.

Key Points:

  • Notch1 signaling impacts key cell types involved in IHD pathogenesis.
  • Notch1 influences critical pathological processes like fibrosis and neovascularization.
  • The pathway plays a role in both disease progression and therapeutic interventions.

Conclusions:

  • Notch1 signaling is implicated in the development and progression of ischemic heart disease.
  • Modulating Notch1 signaling presents a potential therapeutic strategy for IHD.
  • Targeting Notch1 could enhance treatment efficacy for patients suffering from IHD.

Keywords:
Notch1atherosclerosismyocardial infarctionregenerationreperfusion

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