Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Determination of depth for electron breast boosts.

L J Solin1, J C Chu, R Larsen

  • 1Department of Radiation Therapy, University of Pennsylvania School of Medicine, Philadelphia.

International Journal of Radiation Oncology, Biology, Physics
|December 1, 1987
PubMed
Summary

A new technique uses parallel link chains and imaging to accurately measure tumor bed depth for electron boost radiation in early-stage breast cancer patients, improving treatment precision.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration.

Journal of systems and integrative neuroscience·2020
Same author

Importance of neuroanatomical data from domestic animals to the development and testing of the KNDy hypothesis for GnRH pulse generation.

Domestic animal endocrinology·2020
Same author

Refined estimates of local recurrence risks by DCIS score adjusting for clinicopathological features: a combined analysis of ECOG-ACRIN E5194 and Ontario DCIS cohort studies.

Breast cancer research and treatment·2018
Same author

Kisspeptin, gonadotrophin-releasing hormone and oestrogen receptor α colocalise with neuronal nitric oxide synthase neurones in prepubertal female sheep.

Journal of neuroendocrinology·2017
Same author

Does Dynorphin Play a Role in the Onset of Puberty in Female Sheep?

Journal of neuroendocrinology·2017
Same author

Impact of psychosocial stress on gonadotrophins and sexual behaviour in females: role for cortisol?

Reproduction (Cambridge, England)·2016

Area of Science:

  • Radiation Oncology
  • Medical Imaging
  • Breast Cancer Treatment

Background:

  • Electron boost treatments are crucial for early-stage breast cancer irradiation.
  • Accurate determination of tumor bed depth is essential for effective electron boost therapy.
  • Current methods for depth determination can be imprecise, potentially affecting treatment outcomes.

Purpose of the Study:

  • To develop and validate a novel technique for precise electron boost treatment depth determination in early-stage breast cancer.
  • To establish a method that utilizes readily available imaging equipment and anatomical markers.
  • To improve the accuracy of electron energy selection for optimal target volume coverage.

Main Methods:

  • A technique involving parallel link chains placed on the breast over the boost site was developed.

Related Experiment Videos

  • Fluoroscopy was used to confirm chain alignment with the radiopaque surgical clips outlining the tumor bed.
  • Orthogonal and/or rotational stereo shift films were obtained using a standard simulator unit.
  • The depth of surgical clips was measured directly from films using the chain image for surface contour.
  • Depth measurements were compared with those obtained from CT scans for validation.

    • Main Results:

    • The developed technique allows for direct measurement or calculation of surgical clip depth from simulator films.
    • Close agreement was demonstrated between the depths measured using the new technique and those from CT scans.
    • This method provides physicians with accurate information to determine appropriate electron energy for boost treatments.

    Conclusions:

    • The described technique offers a reliable and accurate method for determining electron boost treatment depth in early-stage breast cancer.
    • This approach enhances precision in radiation oncology by enabling accurate target volume coverage.
    • The method's validation against CT scans supports its clinical utility in definitive breast cancer irradiation.