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Thalassaemia-A global view.

Peter Hokland1, Shahina Daar2, Wael Khair3

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|February 17, 2023
PubMed
Summary
This summary is machine-generated.

Management of beta thalassaemia in adolescents varies globally due to resource disparities. Standard care like transfusions and iron chelation is challenging, while therapy adherence remains a universal issue.

Keywords:
diagnosisglobal viewrefugeethalassaemiatherapy

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Area of Science:

  • Hematology
  • Genetics
  • Global Health

Background:

  • Thalassaemias are genetic hemoglobin disorders prevalent globally due to migration.
  • Standard care involves regular transfusions and iron chelation therapy.
  • Access to novel treatments like bone marrow and gene therapy is limited in resource-poor nations.

Purpose of the Study:

  • To present management strategies for adolescent beta thalassaemia patients.
  • To compare approaches across six countries with varying economic resources.
  • To highlight disparities in treatment availability and adherence challenges.

Main Methods:

  • Expert hematologists from Italy, Lebanon, Oman, Sudan, Thailand, and the US described their management practices.
  • Practices were adapted based on locally available resources.
  • Adherence challenges during adolescence were assessed.

Main Results:

  • Significant variations in standard care (transfusions, chelation) delivery were observed.
  • Providing adequate transfusions and chelation remains problematic in many regions.
  • Ensuring therapy adherence in adolescents is a common challenge across all studied countries.

Conclusions:

  • Global disparities in thalassaemia treatment access persist.
  • Resource limitations significantly impact standard care delivery.
  • Adherence to therapy is a critical, universal challenge requiring tailored solutions.