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Cerebral phaeohyphomycosis in a dog.

G Migaki1, H W Casey, W B Bayles

  • 1Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

Journal of the American Veterinary Medical Association
|October 15, 1987
PubMed
Summary

A dog diagnosed with cerebral phaeohyphomycosis experienced seizures and blood abnormalities. Fungal elements were discovered in brain lesions, indicating a severe fungal infection in the central nervous system.

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Area of Science:

  • Veterinary Neurology
  • Mycology
  • Immunology

Background:

  • Cerebral phaeohyphomycosis is a rare fungal infection affecting the brain.
  • Demodectic mange treatment can sometimes be associated with immunosuppression.

Observation:

  • A 9-year-old dog presented with epileptic convulsions preceding death.
  • The dog had a history of severe demodectic mange treated 6 weeks prior.
  • Blood analyses revealed persistent leukopenia, lymphocytopenia, and thrombocytopenia.

Findings:

  • Necropsy identified multiple large pyogranulomatous lesions in the cerebrum and meninges.
  • Microscopic examination revealed dematiaceous fungi with characteristic hyphae and yeast forms within brain tissue.
  • Fungal elements were present in both tissue cells and necrotic areas.

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Implications:

  • This case highlights cerebral phaeohyphomycosis as a potential cause of neurological disease in dogs.
  • The findings suggest a possible link between immunosuppression from mange treatment and susceptibility to systemic fungal infections.
  • Early diagnosis and treatment of fungal meningoencephalitis are crucial for improving outcomes in affected animals.