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A novel tetracycline from Actinomadura brunnea. Fermentation, isolation and structure elucidation
M Patel1, V P Gullo, V R Hegde
1Department of Microbial Products, Schering Corporation, Bloomfield, NJ 07003.
The Journal of Antibiotics
|October 1, 1987
Abstract:
A novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.