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Mitochondrial quality control in acute kidney disease
Jingyi Sheng1, Xian Li2, Juan Lei1
1Department of Pediatric Nephrology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Journal of Nephrology
|February 17, 2023
Summary
Mitochondrial quality control is vital for kidney function but is disrupted in acute kidney disease (AKD). This review explores AKD
Area of Science:
- Nephrology
- Mitochondrial Biology
- Cellular Physiology
Background:
- Acute kidney disease (AKD) involves complex pathogenic mechanisms affecting renal cells.
- Mitochondria are central to cellular energy production and homeostasis.
- Proper mitochondrial function, including quality control, is essential for kidney health.
Purpose of the Study:
- To review the mechanisms of mitochondrial quality control in the context of AKD.
- To highlight the disruption of mitochondrial quality control pathways in AKD.
- To provide insights for developing novel clinical treatments for AKD.
Main Methods:
- Literature review of studies on mitochondrial quality control and AKD.
- Analysis of mechanisms including mitochondrial bioenergetics, biogenesis, dynamics, and mitophagy.
- Synthesis of evidence linking mitochondrial dysfunction to AKD pathogenesis.
Main Results:
- Mitochondrial quality control pathways are significantly disrupted during AKD.
- Impaired mitochondrial homeostasis contributes to renal cell injury in AKD.
- Specific mechanisms like altered mitophagy and dynamics are implicated in AKD.
Conclusions:
- Restoring mitochondrial quality control may offer therapeutic strategies for AKD.
- Targeting mitochondrial pathways presents a promising avenue for AKD treatment.
- Further research into mitochondrial mechanisms is crucial for advancing AKD clinical management.
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