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Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor K-259-2
T Yasuzawa1, M Yoshida, K Shirahata
1Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
The Journal of Antibiotics
|August 1, 1987
Abstract:
The structure of K-259-2, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 3-(2Z-2-ethyl-2-butenyl)-1,6,8-trihydroxy-anthraquinone-2-carboxyl ic acid by chemical conversion and spectral studies.