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Updated: May 13, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1
T Yasuzawa1, M Yoshida, K Shirahata
1Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Abstract:
The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11- tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.
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