Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort
Ashleigh Barrett-Young1, Antony Ambler, Kirsten Cheyne
1From the Dunedin Multidisciplinary Health and Development Research Unit (Barrett-Young, Cheyne, Guiney, Kokaua, Poulton); Department of Psychology (Barrett-Young, Cheyne, Guiney, Poulton), University of Otago, Dunedin, New Zealand; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (Ambler), King's College London, London, United Kingdom; Va'a O Tautai-Centre for Pacific Health (Kokaua), University of Otago, Dunedin, New Zealand; Singapore Eye Research Institute (Tham, Wong), Singapore National Eye Centre, Singapore; Duke-NUS Medical School (Tham, Wong), Singapore; and Department of Medicine, Otago Medical School (Williams, Wilson), University of Otago, Dunedin, New Zealand.
Objective:
We investigated whether childhood social isolation was associated with retinal neural layer changes in adulthood, and whether this association was independent of other childhood or adulthood risk factors, including adult social isolation.
Methods:
Participants were members of the Dunedin Multidisciplinary Health and Development Study, a longitudinal population-based birth cohort from Aotearoa New Zealand ( n = 1037), born 1972 to 1973 and followed until age 45 years, with 94% of the living cohort still participating. Social isolation was recorded prospectively at ages 5, 7, 9, and 11 years, from teacher and parent report. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thicknesses were measured via optical coherence tomography at age 45 years.
Results:
Childhood social isolation was associated with thinner average RNFL ( B = -0.739, p = .02), nasal RNFL ( B = -1.118, p = .005), and inferior RNFL ( B = -1.524, p = .007), although only nasal RNFL remained significant after adjustment. These associations were not fully explained by other psychosocial or physical health risk factors in childhood or adulthood, nor were they mediated by adult loneliness or social support.
Conclusions:
Childhood social isolation was an independent predictor of RNFL thickness in middle age. Highlighting prospective links between childhood psychosocial adversity and retinal neuronal measures will help to inform future research into the utility of retinal neuronal thickness as a biomarker for neurodegeneration.
