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Macrolide biosynthesis: stereochemistry of the hydroxylation of brefeldin C
M Gonzalez de la Parra1, C R Hutchinson
1School of Pharmacy, University of Wisconsin, Madison 53706.
The Journal of Antibiotics
|August 1, 1987
Abstract:
Brefeldin C (2) is the penultimate intermediate in the biosynthetic pathway to brefeldin A (1). Using stereospecifically 2H-labeled forms of 2, the hydroxylation of 2 to 1 is shown to involve stereospecific removal of the 7 pro-S hydrogen from 2.