Wilson disease in pregnancy: A case series

Area of Science:

• Reproductive medicine
• Genetics
• Hepatology

Background:

• Wilson disease (WD) is an inherited disorder of copper metabolism with severe implications during pregnancy, increasing risks for both mother and child.
• Pregnancy in women with WD is associated with high rates of miscarriage, premature birth, and perinatal mortality.

Purpose of the Study:

• To review the management and outcomes of four pregnant women with Wilson disease.
• To highlight the importance of multidisciplinary care and treatment adherence in achieving successful pregnancy outcomes for women with WD.

Main Methods:

• Case series describing four pregnant women with a history of Wilson disease.
• Details on pre-pregnancy medication status, disease severity during pregnancy, treatment adherence, and interventions (copper-chelating drugs, low-copper diet).

Main Results:

• Three out of four women delivered healthy, premature infants.
• One woman experienced a spontaneous abortion at 25 weeks gestation.
• Outcomes were influenced by disease severity and adherence to treatment protocols.

Conclusions:

• Comprehensive monitoring and multidisciplinary management are vital for improving pregnancy outcomes in women with Wilson disease.
• Despite the inherent risks, successful pregnancies and improved quality of life are achievable with appropriate medical support.