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Making bubbles: Targeting VPS41 induces vacuolization and methuosis
Nienke Julia Dekker1, Luca Laraia1
1Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Cell Chemical Biology
|February 21, 2023
Abstract:
In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

