Related Experiment Video
Updated: Jul 30, 2026

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
Published on: December 8, 2016
A Stepwise Replicable Approach to Negotiating Value-driven Supply Chain Contracts for Orthobiologics
Anshal Gupta1, James Lee, Amanda Chawla
1From the Department of Pediatric Orthopaedics, Stanford University (Gupta, McFarlane, and Shea); the Division of Supply Chain Management, Stanford Healthcare (Lee, Chawla, Rajagopalan, Kohler, and Moelling); the Department of Orthopaedics, Stanford University (Ratliff, Hu, and Shea); the Department of Neurosurgery, Stanford University (Ratliff, and Hu); and the Department of Pediatric Surgery, Stanford University, Stanford, CA (Sheth, Wall, and Shea).
Implementing a strategic sourcing program for orthobiologics significantly reduced costs for health systems. This approach engaged clinicians and streamlined vendor contracts, leading to substantial annual savings and improved value.
Area of Science:
- Orthobiologics and Tissue Engineering
- Health Systems Management
- Supply Chain Optimization
Background:
- Orthobiologics are increasingly utilized for tissue healing, yet health systems often fail to realize expected cost savings from high-volume purchasing.
- A gap exists in optimizing the procurement of these valuable biological products within healthcare settings.
Purpose of the Study:
- To evaluate an institutional program designed to prioritize high-value orthobiologics.
- To incentivize vendor participation in value-driven contractual agreements to reduce healthcare costs.
Main Methods:
- A three-step approach involving surgeon expertise in purchasing, defining eight orthobiologic formulary categories with capitated pricing, and a competitive bidding process.
- Pricing benchmarks were set at the 10th percentile for multi-vendor products and 25th for rare products, based on institutional and market data.
- Clinicians and supply chain leaders jointly awarded contracts to vendors meeting pricing expectations.
Main Results:
- Achieved actual annual savings of $542,216, exceeding the projected estimate of $423,946.
- Seventy-nine percent of savings originated from allograft products, with average pricing decreasing across seven of eight formulary categories.
- Vendor consolidation reduced the total number of vendors from 14 to 11, with returning vendors securing larger, multi-year contracts.
Conclusions:
- A replicable three-step strategy effectively increases institutional savings for orthobiologic products.
- Engaging clinician experts and strengthening vendor relationships through consolidated contracts enhances value for health systems.
- This vendor consolidation model creates a win-win scenario, reducing complexity for health systems and increasing market share for vendors.
Related Concept Videos
Drug Products: Biologics, Biosimilars and Interchangeables
Upstream Processing

