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Peptide-based formula: Clinical applications and benefits.
Osman Mohamed Elfadil1, Raj N Shah1, Ryan T Hurt1,2,3
1Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.
Summary
Peptide-based formulas (PBFs) may improve enteral nutrition tolerance in patients with enteral feeding intolerance (EFI). This approach could enhance clinical outcomes and reduce healthcare costs.
Area of Science:
- Clinical Nutrition
- Gastroenterology
- Medical Nutrition Therapy
Background:
- Enteral nutrition (EN) use is increasing, but enteral feeding intolerance (EFI) is a common challenge, hindering adequate nutrient delivery.
- Lack of consensus exists for managing EFI due to patient variability and formula options.
Approach:
- This review explores peptide-based formulas (PBFs) as a strategy to improve EN tolerance.
- PBFs contain enzymatically hydrolyzed proteins (dipeptides and tripeptides) and often higher medium-chain triglyceride content for enhanced absorption.
Key Points:
- PBFs are designed for easier absorption and utilization.
- Emerging data suggest PBFs can improve clinical outcomes in patients with EFI.
- Potential benefits include reduced healthcare utilization and cost savings.
Conclusions:
- Peptide-based formulas represent a promising approach for managing enteral feeding intolerance.
- Further research and clinical application of PBFs warrant consideration for optimizing patient nutrition.
