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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

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Smart "Thrombus": Self-Localizing UCST-Type Microcage.

Shenglong Gan^1,2,3, Jiao Dong^1,2, Xian Li⁴

¹Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays, South P. R. China Academy of Advanced Optoelectronics, South P. R. China Normal University, Guangzhou 510006, P. R. China.

ACS Macro Letters

|February 21, 2023

Summary

Researchers developed smart microcages from a temperature-sensitive polymer for targeted embolization. These microcages offer controlled drug release and imaging capabilities for fibroid and tumor treatments.

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Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

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Published on: June 15, 2012

Area of Science:

Biomaterials Science
Polymer Chemistry
Medical Imaging

Background:

Embolization therapy is crucial for managing fibroids and tumors by blocking blood supply.
Current embolic agents lack targeted delivery and removal capabilities, limiting their efficacy.
Developing smart embolic agents with controlled release and targeting is a significant clinical need.

Purpose of the Study:

To engineer novel, self-localizing microcages for enhanced embolization therapies.
To investigate the potential of a temperature-sensitive polymer for creating stimuli-responsive embolic agents.
To evaluate the multifunctional capabilities of these microcages for tumor starving therapy, chemotherapy, and imaging.

Main Methods:

Utilized nonionic poly(acrylamide-co-acrylonitrile) with an upper critical solution temperature (UCST) to synthesize microcages via inverse emulsification.
Characterized the phase-transition properties of the UCST-type microcages, focusing on their behavior around 40 °C.
Assessed the expansion-fusion-fission cycle and cargo release under mild hyperthermia conditions.

Main Results:

The synthesized UCST-type microcages exhibited a suitable phase-transition threshold near 40 °C.
Microcages demonstrated spontaneous expansion, fusion, and fission cycles in response to mild hyperthermia.
Simultaneous local release of encapsulated cargoes was observed, confirming their responsiveness.

Conclusions:

The developed UCST-type microcages represent a promising smart biomaterial for embolization.
These microcages offer potential for targeted tumor starving therapy, chemotherapy, and medical imaging.
The stimuli-responsive nature of the microcages facilitates multifunctional therapeutic applications.