Related Experiment Video

Updated: Aug 9, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

25.6K

In-stent restenosis and stented-territory infarction after carotid and vertebrobasilar artery stenting

Jae-Chan Ryu1, Jae-Han Bae1, Sang Hee Ha2

  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

BMC Neurology
|February 21, 2023
PubMed

Insights

Vertebrobasilar stenting (VBS) showed higher rates of stented-territory infarction compared to carotid artery stenting (CAS). In-stent restenosis was linked to infarction in CAS, but not VBS, suggesting different underlying mechanisms.

Area of Science:

  • Vascular Surgery
  • Interventional Neurology
  • Cardiovascular Research

Background:

  • Prognosis following vertebrobasilar stenting (VBS) may differ from carotid artery stenting (CAS).
  • Direct comparison of in-stent restenosis and stented-territory infarction incidence and predictors between VBS and CAS is needed.

Purpose of the Study:

  • To directly compare the incidence and predictors of in-stent restenosis and stented-territory infarction after VBS versus CAS.
  • To elucidate potential differences in the mechanisms of stented-territory infarction between VBS and CAS.

Main Methods:

  • A comparative study enrolled patients undergoing VBS or CAS.
  • Follow-up for 3 years investigated in-stent restenosis (>50% lumen diameter reduction) and stented-territory infarction.
  • Clinical and procedural factors were analyzed to identify predictors for both outcomes in each group.

Main Results:

  • No significant difference in in-stent restenosis rates between VBS (12.9%) and CAS (6.8%).
  • Stented-territory infarction was significantly more frequent after VBS (22.6%) than CAS (10.8%), particularly within a month post-procedure.
  • Predictors for in-stent restenosis included HbA1c, clopidogrel resistance, and multiple stents (VBS); young age (CAS). Diabetes and multiple stents predicted infarction in VBS, while in-stent restenosis predicted infarction in CAS.

Conclusions:

  • Stented-territory infarction occurs more frequently after VBS, especially in the periprocedural period.
  • In-stent restenosis is a predictor of stented-territory infarction after CAS, but not VBS.
  • The mechanisms driving stented-territory infarction appear distinct between VBS and CAS.
Abstract

Keywords:
Carotid stentIn-stent restenosisIschemic strokeVertebrobasilar stent

More Related Videos

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery09:41

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery

Published on: December 23, 2014

16.5K
A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application06:53

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Published on: July 9, 2020

5.1K

Related Concept Videos

Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
15
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
16
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
46