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The cost of competency?

Yun-Ruei Kao1, Britta Will2

  • 1Department of Medicine (Oncology), Albert Einstein College of Medicine / Montefiore Medical Center, Bronx, NY, USA.

Cell
|February 21, 2023
PubMed

Curtailed protein translation ensures stemness and multipotency in embryonic and adult tissue-specific stem cells. In this issue of Cell, a study led by Zhao and colleagues uncovered increased susceptibility of hematopoietic stem cells (HSC) to iron-dependent programmed necrotic cell death (ferroptosis) as a consequence of low protein synthesis.

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