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Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

Zitu Barman1, Mahmudul Hasan1, Rakib Miah1

  • 1Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.

BMC Endocrine Disorders
|February 21, 2023
PubMed

Insights

High uric acid levels (hyperuricemia) are independently linked to chronic kidney disease (CKD) in Bangladeshi adults. This study highlights a significant association, suggesting hyperuricemia as a potential risk factor for CKD.

Area of Science:

  • Nephrology
  • Public Health
  • Metabolic Disorders

Background:

  • Chronic kidney disease (CKD) is a global health issue and a major risk factor for cardiovascular disease.
  • Hyperuricemia is associated with obesity, hypertension, cardiovascular disease, and diabetes, but its link to CKD requires further investigation.

Purpose of the Study:

  • To determine the prevalence of CKD in Bangladeshi adults.
  • To assess the relationship between hyperuricemia and CKD in this population.

Main Methods:

  • Blood samples from 545 adults (≥18 years) were analyzed for serum uric acid (SUA), glucose, creatinine, and urea.
  • Estimated glomerular filtration rate (eGFR) and CKD were calculated using serum creatinine levels.
  • Multivariate logistic regression analyzed the association between SUA and CKD.

Main Results:

  • The prevalence of CKD was 5.9%, with hyperuricemia found in 18.7% of participants.
  • Mean SUA levels were significantly higher in participants with CKD compared to those without (7.1 vs. 5.7 mg/dL).
  • CKD prevalence increased with higher SUA quartiles, and eGFR decreased significantly across these quartiles (p < 0.001).

Conclusions:

  • Hyperuricemia shows an independent association with CKD in Bangladeshi adults.
  • Further research is recommended to elucidate the underlying mechanisms connecting hyperuricemia and CKD.
Abstract

Keywords:
BangladeshChronic kidney diseaseHyperuricemiaSUAeGFR

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