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Recent progress of 4D printing in cancer therapeutics studies
Atchara Chinnakorn1, Wiwat Nuansing1, Mahdi Bodaghi2
1School of Physics, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Abstract:
Cancer is a critical cause of global human death. Not only are complex approaches to cancer prognosis, accurate diagnosis, and efficient therapeutics concerned, but post-treatments like postsurgical or chemotherapeutical effects are also followed up. The four-dimensional (4D) printing technique has gained attention for its potential applications in cancer therapeutics. It is the next generation of the three-dimensional (3D) printing technique, which facilitates the advanced fabrication of dynamic constructs like programmable shapes, controllable locomotion, and on-demand functions. As is well-known, it is still in the initial stage of cancer applications and requires the insight study of 4D printing. Herein, we present the first effort to report on 4D printing technology in cancer therapeutics. This review will illustrate the mechanisms used to induce the dynamic constructs of 4D printing in cancer management. The recent potential applications of 4D printing in cancer therapeutics will be further detailed, and future perspectives and conclusions will finally be proposed.
Insights
Four-dimensional (4D) printing, an advanced fabrication technique, shows promise for novel cancer therapeutics. This review explores its mechanisms and applications in cancer management, paving the way for future innovations.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Cancer remains a leading global cause of mortality, necessitating advancements in prognosis, diagnosis, and treatment.
- Post-treatment monitoring, including postsurgical and chemotherapeutical effects, is crucial for patient outcomes.
- Current cancer therapeutic strategies require continuous innovation to improve efficacy and patient care.
Approach:
- This review introduces four-dimensional (4D) printing as a next-generation fabrication technique for dynamic constructs.
- It details the mechanisms enabling programmable shapes, controllable locomotion, and on-demand functions in 4D-printed materials.
- The study focuses on the initial applications and potential of 4D printing in cancer therapeutics.
Key Points:
- 4D printing enables the creation of dynamic and responsive materials for targeted cancer therapies.
- Mechanisms for inducing shape-changing and functional behaviors in 4D constructs are explored.
- The review highlights recent advancements and potential applications of 4D printing in various aspects of cancer treatment.
Conclusions:
- 4D printing technology is in its nascent stages for cancer applications, requiring further research and development.
- This technology offers a promising avenue for developing innovative and personalized cancer therapeutics.
- Future perspectives suggest significant potential for 4D printing to revolutionize cancer management and treatment strategies.
