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Updated: Aug 9, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Vascular function and cognition in persons with multiple sclerosis: Preliminary examination.

Peixuan Zheng1, Lara A Pilutti2, Noah G DuBose1

  • 1Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States.

Multiple Sclerosis and Related Disorders
|February 22, 2023
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Summary

Arterial stiffness, measured by pulse wave velocity, is linked to slower cognitive processing speed in multiple sclerosis (MS) patients. This finding may inform early interventions for cognitive decline in MS.

Keywords:
Arterial stiffnessAugmentation indexCognitive functionMultiple sclerosisPulse wave velocity

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Area of Science:

  • Neurology
  • Cardiovascular Science
  • Cognitive Neuroscience

Background:

  • Cognitive dysfunction is a common MS symptom.
  • Vascular comorbidities are increasingly recognized in MS.
  • Evidence linking vascular biomarkers to MS cognition is limited.

Purpose of the Study:

  • To compare vascular function in MS patients versus controls.
  • To investigate associations between vascular and cognitive function in MS.

Main Methods:

  • Characterized differences in vascular function.
  • Examined associations between arterial stiffness (cfPWV, AIx75) and cognitive tests (SDMT).
  • Utilized bivariate correlations and regression analyses.

Main Results:

  • MS patients exhibited poorer cognitive performance and higher cfPWV than controls.
  • Significant correlations found between SDMT scores and AIx75/cfPWV in the MS group.
  • Nonlinear association identified between cfPWV and SDMT in MS.

Conclusions:

  • Arterial stiffness is associated with cognitive processing speed in MS.
  • Supports further research into vascular function's role in MS cognition.
  • Suggests potential for vascular interventions to prevent cognitive impairment in MS.