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Ultrasonic-controlled "explosive" hydrogels to precisely regulate spatiotemporal osteoimmune disturbance
Xiaoyu Han1, Jieliang Shen2, Shuyu Chen3
1Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.
Ultrasound Controlled "Explosive" (UCE) hydrogels precisely regulate bone immune disorders by releasing resveratrol. This targeted approach suppresses early inflammation, accelerating fracture healing and improving bone tissue repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Immunology
Background:
- Spatiotemporal immune dysregulation hinders bone tissue healing.
- Controlling the early-phase excessive immune response is crucial for bone repair.
- Osteoimmune disorders disrupt the balance between inflammation and bone formation.
Purpose of the Study:
- To develop ultrasound-responsive hydrogels for controlled drug delivery.
- To investigate the spatiotemporal regulation of osteoimmune disorders.
- To enhance bone tissue healing by modulating early inflammatory responses.
Main Methods:
- Fabrication of gelatin-hyaluronic acid methacrylate hydrogels loaded with resveratrol nanobubbles.
- Utilizing Ultrasound Controlled "Explosive" (UCE) technology for triggered drug release.
- In vivo evaluation of UCE hydrogels for anti-inflammatory and osteogenic effects.
Main Results:
- UCE hydrogels demonstrated controlled release of resveratrol (38.14%) under ultrasound (1.5 W/cm²).
- UCE hydrogels effectively inhibited local inflammation and promoted osteogenesis in vivo compared to controls.
- Resveratrol release from UCE hydrogels precisely regulated temporospatial bone immune disorders.
Conclusions:
- UCE hydrogels offer a novel strategy for precise spatiotemporal control of osteoimmune responses.
- Targeted intervention of peak inflammation in early fracture healing accelerates bone repair.
- This technology holds promise for improving outcomes in bone tissue regeneration.
