Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The polymorphic metabolism of dextromethorphan.

J R Woodworth1, S R Dennis, L Moore

  • 1Pennwalt Pharmaceutical Division, Rochester, New York.

Journal of Clinical Pharmacology
|February 1, 1987
PubMed
Summary

This study investigated dextromethorphan (DM) metabolism in healthy volunteers, finding most are fast metabolizers. Intermediate metabolizers may indicate a novel genetic polymorphism distinct from debrisoquin metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining constructs of high-quality rural health student placements: a multiple case ECOUTER study.

BMC health services research·2026
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

Validation of a stall-side immunoglobulin assay for use in equine reproductive management.

Equine veterinary journal·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025

Area of Science:

  • Pharmacogenetics
  • Drug Metabolism
  • Human Physiology

Background:

  • Dextromethorphan (DM) metabolism varies significantly among individuals.
  • Understanding metabolic phenotypes is crucial for personalized medicine and drug development.
  • Previous studies linked slow DM metabolism to debrisoquin metabolism, but intermediate phenotypes remain less understood.

Purpose of the Study:

  • To characterize the metabolic profiles of dextromethorphan (DM) in a healthy American population.
  • To determine the prevalence of fast, intermediate, and slow DM metabolizers.
  • To explore potential correlations between DM metabolic phenotypes and debrisoquin metabolism.

Main Methods:

  • A 30-mg oral dose of dextromethorphan was administered to 252 healthy male volunteers.

Related Experiment Videos

  • Plasma concentrations of unchanged DM were measured at 4 and 24 hours post-administration.
  • Metabolizer status (fast, intermediate, slow) was determined based on plasma DM levels and elimination-rate constants.

    • Main Results:

    • The study population comprised 84.3% fast DM metabolizers, 6.8% intermediate metabolizers, and 8.8% slow metabolizers.
    • A correlation was observed between slow DM metabolizers and slow debrisoquin metabolizers.
    • No significant correlation was found between intermediate DM metabolizers and debrisoquin metabolism.

    Conclusions:

    • The majority of the studied American population are fast dextromethorphan metabolizers.
    • The distinct metabolic behavior of intermediate DM metabolizers suggests a potential novel genetic polymorphism.
    • Further research is warranted to elucidate the genetic basis and implications of intermediate DM metabolism, potentially revealing complexities in drug-metabolizing enzyme regulation.