Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Mitochondria01:37

Mitochondria

14.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Live music enhances self-reported audience immersion and physiological synchrony compared to live-streaming.

Scientific reports·2026
Same author

Small-molecule modulation of β-arrestins.

Nature·2026
Same author

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists.

bioRxiv : the preprint server for biology·2026
Same author

In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer.

Nature communications·2026
Same author

Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation.

The Journal of biological chemistry·2026
Same author

A stationary phase-specific bacterial green light sensor for enhancing metabolite production.

Nature communications·2025

Related Experiment Video

Updated: Aug 9, 2025

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

377

Increased alcohol dehydrogenase 1 activity promotes longevity.

Abbas Ghaddar1, Vinod K Mony1, Swarup Mishra2

  • 1Department of Biology, College of Arts and Sciences, University of Virginia, Charlottesville, VA 22903, USA.

Current Biology : CB
|February 22, 2023
PubMed
Summary

Scientists identified a key downstream effector, alcohol dehydrogenase (ADH-1), that drives longevity across species. Overexpressing ADH-1 extends healthspan and lifespan by reducing aging-promoting glycerol levels.

Keywords:
aging, healthspanalcoholaldehydecaloric restrictionglycerolhlh-30/TFEBlifespanlongevitymTOR/insulin signaling

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

971
Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

1.6K

Related Experiment Videos

Last Updated: Aug 9, 2025

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

377
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

971
Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

1.6K

Area of Science:

  • Aging research
  • Molecular biology
  • Genetics

Background:

  • Most longevity-promoting molecules are upstream regulators, obscuring fundamental aging mechanisms.
  • Transcription factor EB (TFEB)/HLH-30 is crucial for longevity interventions and extends lifespan when overexpressed.

Purpose of the Study:

  • To identify downstream effectors of TFEB/HLH-30 that are necessary and sufficient for promoting longevity.
  • To elucidate fundamental anti-aging mechanisms by focusing on downstream effectors.

Main Methods:

  • Investigated effectors downstream of TFEB/HLH-30 in C. elegans.
  • Assessed the role of alcohol dehydrogenase (ADH-1) and its mediated anti-aging response (AMAR).
  • Examined ADH-1's effect on glycerol levels and longevity in C. elegans, yeast, and conserved across species.

Main Results:

  • Identified the alcohol-dehydrogenase-mediated anti-aging response (AMAR) as essential for longevity induced by HLH-30 overexpression, caloric restriction, mTOR inhibition, and insulin-signaling deficiency.
  • Sole overexpression of ADH-1 is sufficient to activate AMAR, extend healthspan and lifespan, and reduce glycerol levels.
  • ADH-1 overexpression promotes longevity in yeast, and its orthologs are induced in calorically restricted mice and humans.

Conclusions:

  • ADH-1 acts as a conserved downstream effector driving longevity across phyla.
  • Reducing glycerol, an aging-promoting alcohol, via ADH-1 is a fundamental anti-aging mechanism.
  • The AMAR pathway highlights a key effector for extending healthspan and lifespan.