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Related Experiment Videos

Myopathy with core-like structures in a dog.

S J Newsholme1, C J Gaskell

  • 1Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool.

Journal of Comparative Pathology
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Histological examination revealed core-like structures in a Great Dane with muscle weakness, similar to human congenital muscle disorders like central core disease.

Area of Science:

  • Veterinary Pathology
  • Canine Myopathies
  • Muscle Histology

Background:

  • Congenital muscular disorders are rare conditions affecting muscle development and function.
  • Rod myopathies and central core disease are examples of human congenital myopathies.
  • Understanding these conditions in animals can provide insights into human diseases.

Observation:

  • An 18-month-old Great Dane presented with muscle weakness and proximal muscular atrophy.
  • Histological examination of muscle fibers revealed lightly staining, core-like structures lacking cross-striations.
  • These cores contained vacuoles and nuclei, with scattered necrotic and regenerating fibers also noted.

Findings:

  • Ultrastructural analysis showed disarrayed filament bundles within the cores, attached to thickened Z-lines.

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  • These ultrastructural features are consistent with the pathological findings in rod myopathies.
  • The observed muscle pathology shares similarities with human central core disease.

    • Implications:

    • This case highlights a potential canine model for studying congenital myopathies.
    • Further characterization could elucidate the genetic and molecular basis of this condition in dogs.
    • Comparative studies may advance understanding of muscle diseases in both veterinary and human medicine.